Shanxian Chemical
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Allylamine and Azole Antifungal Agents
Allylamine and azole antifungal agents
In recent years, the medical way is advanced, and in the research of antifungal, allylamine and azole antifungal agents have emerged. Allylamine has a unique effect, can inhibit fungal squalene epoxidase, cause squalene accumulation, membrane formation is blocked, and bacterial life is Que. Its efficacy is fast and strong, and it has good curative effect on dermatophytes, etc., and has good tolerance, and patients are more susceptible to it.
The azole class is divided into imidazole and triazole. With its azole ring structure, it can bind to fungal cytochrome P450, hinder the synthesis of ergosterol, damage the integrity of the membrane, and restrict fungal growth. Imidazoles such as clotrimazole are widely used externally and are effective for surface fungal diseases. Triazoles, such as fluconazole, have a broader antibacterial spectrum, can involve deep fungal diseases, excellent oral absorption, and wide distribution in the body.
However, both also have their own flaws. Allylamine may have local irritation, occasionally allergic. Azoles cause frequent drug interactions due to their impact on the human P450 enzyme system, such as in combination with some anticoagulants, or increase bleeding risk; long-term use, but also lead to liver damage and other concerns.
Doctors should study their properties in detail, weigh the advantages and disadvantages, and make allylamine and azole antifungal agents suitable for clinical use.
In recent years, the medical way is advanced, and in the research of antifungal, allylamine and azole antifungal agents have emerged. Allylamine has a unique effect, can inhibit fungal squalene epoxidase, cause squalene accumulation, membrane formation is blocked, and bacterial life is Que. Its efficacy is fast and strong, and it has good curative effect on dermatophytes, etc., and has good tolerance, and patients are more susceptible to it.
The azole class is divided into imidazole and triazole. With its azole ring structure, it can bind to fungal cytochrome P450, hinder the synthesis of ergosterol, damage the integrity of the membrane, and restrict fungal growth. Imidazoles such as clotrimazole are widely used externally and are effective for surface fungal diseases. Triazoles, such as fluconazole, have a broader antibacterial spectrum, can involve deep fungal diseases, excellent oral absorption, and wide distribution in the body.
However, both also have their own flaws. Allylamine may have local irritation, occasionally allergic. Azoles cause frequent drug interactions due to their impact on the human P450 enzyme system, such as in combination with some anticoagulants, or increase bleeding risk; long-term use, but also lead to liver damage and other concerns.
Doctors should study their properties in detail, weigh the advantages and disadvantages, and make allylamine and azole antifungal agents suitable for clinical use.
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