Shanxian Chemical
SUPPLEMENTS
Alpha Helix Structure Hydrogen Bonding
"On Hydrogen Bonds in the Alpha Helix Structure"
Everything in the world has its own reasons, and in the microscopic domain, the molecular structure also contains the most wonderful way. The alpha helix structure is also the wonder of the microscopic world, in which the role of hydrogen bonds is crucial.
In the alpha helix structure, hydrogen bonds maintain its stable state. The main chain of the polypeptide chain makes a regular spiral rise around the central axis, with a spiral of every 3.6 amino acid residues, and the pitch is about 0.54nm. In this structure, the hydrogen bond is the key bond.
It is formed between the oxygen atom on the carbonyl group of the first peptide plane and the hydrogen atom on the imino group of the fourth peptide plane in the polypeptide chain. The direction of this hydrogen bond is almost parallel to the helix axis. In this way, many hydrogen bonds interact, endowing the α helix structure with specific stability and morphology.
The stability of the α helix structure depends on not only the hydrogen bond, but also the side chain of amino acid residues. If the side chain groups are too large, or the charges repel each other, it may affect the formation and stability of the α helix.
Looking at the relationship between the α helix structure and the hydrogen bond, we can see the subtle relationship between structure and function in the microscopic world. Although it is small, it has far-reaching significance for the function of biological macromolecules. This microscopic mystery needs to be continuously explored and investigated by our generation in order to understand its reason and contribute to the progress of science.
Everything in the world has its own reasons, and in the microscopic domain, the molecular structure also contains the most wonderful way. The alpha helix structure is also the wonder of the microscopic world, in which the role of hydrogen bonds is crucial.
In the alpha helix structure, hydrogen bonds maintain its stable state. The main chain of the polypeptide chain makes a regular spiral rise around the central axis, with a spiral of every 3.6 amino acid residues, and the pitch is about 0.54nm. In this structure, the hydrogen bond is the key bond.
It is formed between the oxygen atom on the carbonyl group of the first peptide plane and the hydrogen atom on the imino group of the fourth peptide plane in the polypeptide chain. The direction of this hydrogen bond is almost parallel to the helix axis. In this way, many hydrogen bonds interact, endowing the α helix structure with specific stability and morphology.
The stability of the α helix structure depends on not only the hydrogen bond, but also the side chain of amino acid residues. If the side chain groups are too large, or the charges repel each other, it may affect the formation and stability of the α helix.
Looking at the relationship between the α helix structure and the hydrogen bond, we can see the subtle relationship between structure and function in the microscopic world. Although it is small, it has far-reaching significance for the function of biological macromolecules. This microscopic mystery needs to be continuously explored and investigated by our generation in order to understand its reason and contribute to the progress of science.
Scan to WhatsApp
