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Dipole Dipole and Hydrogen Bonding

"On Dipole-Dipole Interaction and Hydrogen Bonding"

Between heaven and earth, there is a sense of phase between things. In the microscopic realm, the existence of dipole-dipole interaction and hydrogen bond between molecules is the key to the formation of physical properties.

The so-called dipole-dipole interaction is due to the polarity of molecules. For polar molecules, the positive and negative charge centers do not coincide, so there is a dipole. When the equal molecules are similar, the positive electrode of the molecule attracts the negative electrode of other molecules, which is the dipole-dipole interaction. Although its force is not as strong as the ionic bond, it has a significant impact on the properties of many substances, such as boiling point, melting point, solubility, etc.

As for hydrogen bonding, it is a special kind of dipole-dipole interaction. When a hydrogen atom is connected to an atom with a large electronegativity and a small radius (such as fluorine, oxygen, and nitrogen), the hydrogen atom is partially positively charged and can form a hydrogen bond with another atom with a large electronegativity. The force of hydrogen bonding is stronger than that of ordinary dipole-dipole interactions, and it plays a pivotal role in biological systems, crystal structures, and the characteristics of many compounds.

Consider the properties of water. Its boiling point is abnormally high, and there are hydrogen bonds between positive water molecules. Hydrogen bonds make water molecules attract each other. To vaporize them, more energy is required to overcome this attraction, so the boiling point of water is higher than that of similar compounds. In biological macromolecules such as proteins and nucleic acids, hydrogen bonds maintain their specific structures and functions. The secondary structures of proteins, such as alpha-helices and beta-folds, are formed by hydrogen bonds; the base pairing of nucleic acids is also maintained by hydrogen bonds, which is indispensable for the inheritance and information transmission of life.

From this point of view, although the dipole-dipole interaction and hydrogen bonds are invisible, they are of great power in the nature of all things and the principle of life. Explore its mysteries and understand its laws, so as to go further and gain insight into the subtlety of the material world.