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Hydrogen Peroxide Origin in Body
The source of hydrogen peroxide in the human body
In the human body, hydrogen peroxide comes from multiple sources. One of them is derived from the metabolism of cells. When cells perform respiration, mitochondria are the key places for production capacity. During the operation of the electron transfer chain, occasional electrons escape and combine with oxygen molecules to produce superoxide anions. Superoxide anions can be converted into hydrogen peroxide through the action of superoxide dismutase. This is an important way for endogenous hydrogen peroxide generation in cells.
Furthermore, the process of immune defense is also where hydrogen peroxide is generated. When the body encounters the invasion of pathogens, immune cells such as neutrophils and macrophages will initiate the respiratory burst mechanism. In this process, the NADPH oxidase on the cell membrane is activated, catalyzing the oxidation of NADPH, reducing oxygen molecules to superoxide anions, and then converting them into hydrogen peroxide. Hydrogen peroxide can kill invading pathogens in immune defense and build an important defense line for the body.
In addition, the influence of external factors can also cause the production of hydrogen peroxide in the body. Such as pollutants in the environment, radiation, and drug metabolism, can cause the body to produce reactive oxygen species clusters, which contain hydrogen peroxide. For example, long-term exposure to radiation can easily damage the molecular structure in the cell, triggering a series of oxidative stress reactions that promote the generation of hydrogen peroxide.
In summary, the source of hydrogen peroxide in the human body is not only the physiological process of normal metabolism of cells, but also the need for immune defense, and the role of external factors cannot be underestimated. All sources are intertwined and jointly affect the level of hydrogen peroxide in the body, which has a profound impact on the physiological and pathological processes of the body.
In the human body, hydrogen peroxide comes from multiple sources. One of them is derived from the metabolism of cells. When cells perform respiration, mitochondria are the key places for production capacity. During the operation of the electron transfer chain, occasional electrons escape and combine with oxygen molecules to produce superoxide anions. Superoxide anions can be converted into hydrogen peroxide through the action of superoxide dismutase. This is an important way for endogenous hydrogen peroxide generation in cells.
Furthermore, the process of immune defense is also where hydrogen peroxide is generated. When the body encounters the invasion of pathogens, immune cells such as neutrophils and macrophages will initiate the respiratory burst mechanism. In this process, the NADPH oxidase on the cell membrane is activated, catalyzing the oxidation of NADPH, reducing oxygen molecules to superoxide anions, and then converting them into hydrogen peroxide. Hydrogen peroxide can kill invading pathogens in immune defense and build an important defense line for the body.
In addition, the influence of external factors can also cause the production of hydrogen peroxide in the body. Such as pollutants in the environment, radiation, and drug metabolism, can cause the body to produce reactive oxygen species clusters, which contain hydrogen peroxide. For example, long-term exposure to radiation can easily damage the molecular structure in the cell, triggering a series of oxidative stress reactions that promote the generation of hydrogen peroxide.
In summary, the source of hydrogen peroxide in the human body is not only the physiological process of normal metabolism of cells, but also the need for immune defense, and the role of external factors cannot be underestimated. All sources are intertwined and jointly affect the level of hydrogen peroxide in the body, which has a profound impact on the physiological and pathological processes of the body.
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